A Symposium on Cell Signaling 2016 - Speakers
Byron Goldstein, LANL (Honoree)
Dr. Byron Goldstein is a retired Fellow of the Los Alamos National Laboratory. He is a recipient of the 2003 National Institute of General Medical Sciences MERIT award for the study of receptor aggregation and its effects. In the mid 1970's, Dr. Goldstein was recruited to join the newly formed Theoretical Biology and Biophysics Group within Los Alamos's renowned Theoretical Division. From that point on, he studied various aspects of the immune system, in particular allergic reactions triggered by the high-affinity receptor for IgE antibody. Dr. Goldstein studied IgE receptor signaling for over 35 years, working with many of the leading experimentalists in the field over that time. He developed a great number of models relating antigen properties to antigen-induced signaling events and cellular responses, and he made important contributions to our understanding of how ligand dose, valence, and binding kinetics influence downstream receptor signaling events. He is recognized for his biophysical modeling of ligand-receptor interactions, for modeling intracellular signaling processes in mammalian cell signaling systems that play roles in immunity, and for developing novel approaches for modeling the dynamics of biochemical networks. He became a LANL Fellow in 2004, an AAAS Fellow in 2011.